APA
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Phan, V., Mathiyalagan, R., Nguyen, M.-T., Tran, T.-T., Murugesan, M., Ho, T., … Thambi, T. (2022). Ionically cross-linked alginate-chitosan core-shell hydrogel beads for oral delivery of insulin. International Journal of Biological Macromolecules.
Chicago/Turabian
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Phan, V., Ramya Mathiyalagan, Minh-Thu Nguyen, Thanh-Tuyen Tran, Mohanapriya Murugesan, Tuyet Ho, H. Hương, D. Yang, Yi Li, and Thavasyappan Thambi. “Ionically Cross-Linked Alginate-Chitosan Core-Shell Hydrogel Beads for Oral Delivery of Insulin.” International Journal of Biological Macromolecules (2022).
MLA
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Phan, V., et al. “Ionically Cross-Linked Alginate-Chitosan Core-Shell Hydrogel Beads for Oral Delivery of Insulin.” International Journal of Biological Macromolecules, 2022.
BibTeX Click to copy
@article{v2022a,
title = {Ionically cross-linked alginate-chitosan core-shell hydrogel beads for oral delivery of insulin.},
year = {2022},
journal = {International Journal of Biological Macromolecules},
author = {Phan, V. and Mathiyalagan, Ramya and Nguyen, Minh-Thu and Tran, Thanh-Tuyen and Murugesan, Mohanapriya and Ho, Tuyet and Hương, H. and Yang, D. and Li, Yi and Thambi, Thavasyappan}
}
Here, core-shell hydrogel beads for oral insulin delivery at intestine was reported, which was a target site for insulin absorption. The core-shell hydrogel beads were prepared using naturally derived alginate and chitosan polysaccharides by simple dropping technique. In order to effectively control leakage of insulin from core-shell hydrogel beads, insulin was embedded into the layered double hydroxides (LDHs). LDH/insulin-loaded complexes were firstly coated with chitosan, and then coated with alginate to generate core-shell hydrogel beads. The biocompatibility and angiogenic response of core-shell hydrogel beads were evaluated by direct contact of the beads with chick embryo chorioallantoic membrane, which indicates safety of the core-shell beads. The beads successfully retained the insulin within the core-shell structure at pH 1.2, indicating that insulin had a good protective effect in harsh acidic environments. Interestingly, insulin release starts at the simulated intestinal fluid (pH 6.8) and continue to release for 24 h in a sustained manner.